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Human T Cell Clones

Human T Cell Clones

Author: Marc Feldmann

Publisher: Springer Science & Business Media

ISBN: 9781461249986

Category: Medical

Page: 455

View: 970

Most complex biological systems, such as enzyme pathways, are effec tively controlled near the beginning of the process. There is increasing evidence that the same is true for the immune system, with the initial interactions between antigen, antigen-presenting cells, and T cells hav ing a paramount influence on the ensuing events. Thus, analysis of the early stages of the immune responses has been a preoccupation of many immunologists. This has been considerably aided by the capac ity to expand these early events, and 'immortalize' them as clones of T cells, for detailed analysis. The discovery by Morgan, Ruscetti, and Gallo (Science 193, 1007, 1976) of T-cell growth factor (now termed interleukin-2 or IL-2) has had a major impact in immunology that is far from over. The greater ease of handling murine tissues experimentally, with the availability of more precisely defined reagents such as inbred strains, has meant that, to date, most of the work on long-term T-cell cultures has been per formed in the mouse, as summarized by Fathman and Fitch (eds. , Iso lation, Characterization and Utilization of T Lymphocyte Clones, Aca demic Press, NY, 1982). However, the limitations of working with human tissues are counterbalanced by the great long-term importance of understanding disorders of human immune regulation, especially since it is becoming evident that these are far from rare. Immune deficiencies such as agammaglobulinemia and T-cell deficiencies are not common, but immune hyperresponsiveness occurring in allergy and allergiC diseases (e. g.
Human T Cell Clones
Language: en
Pages: 455

Human T Cell Clones

Authors: Marc Feldmann, Jonathan R. Lamb, James N. Woody
Categories: Medical
Type: BOOK - Published: 2012-12-06 - Publisher: Springer Science & Business Media

Most complex biological systems, such as enzyme pathways, are effec tively controlled near the beginning of the process. There is increasing evidence that the same is true for the immune system, with the initial interactions between antigen, antigen-presenting cells, and T cells hav ing a paramount influence on the ensuing
T Cell Clones
Language: en
Pages: 339

T Cell Clones

Authors: Harald von Boehmer, Werner Haas
Categories: Medical
Type: BOOK - Published: 1985 - Publisher: Elsevier Science Limited

Books about T Cell Clones
Human T Cell Clones
Language: en
Pages: 122

Human T Cell Clones

Authors: Frank Emmrich
Categories: Antigens
Type: BOOK - Published: 1985 - Publisher:

Books about Human T Cell Clones
The Human T-Cell Receptor Repertoire and Transplantation
Language: en
Pages: 173

The Human T-Cell Receptor Repertoire and Transplantation

Authors: Peter van den Elsen
Categories: Medical
Type: BOOK - Published: 2013-06-29 - Publisher: Springer Science & Business Media

these analyses it became clear that the MHC class I molecule com prised a distinct groove on the external side of the molecule. The sides of the groove are formed by the a-helical structures of the a and a 1 2 domains and a floor which is formed by 8
Isolation Characterization, and Utilization of T Lymphocyte Clones
Language: en
Pages: 580

Isolation Characterization, and Utilization of T Lymphocyte Clones

Authors: C Fathman
Categories: Medical
Type: BOOK - Published: 2012-12-02 - Publisher: Elsevier

Isolation, Characterization, and Utilization of T Lymphocyte Clones is a summary of information regarding T lymphocyte clones, including their usefulness. Organized into nine parts, the book begins with discussions on the soluble factors that can influence the growth of cloned T cells and the utilization of T cell hybridomas for

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